Drug Information

Drug General Information
Drug ID
D0GC2M
Former ID
DAP000857
Drug Name
Acamprosate
Synonyms
AOTA; Acamprosato; Acamprosatum; Acamprostate; Aotal; Campral; Calcium acetyl homotaurinate; Calcium acetylhomotaurinate; Calcium acetylhomotaurine; Sodium acetylhomotaurine; Acamprosate 6473; Acamprosate (Campral); Acamprosate (INN); Acamprosate [INN:BAN]; Acamprosato [INN-Spanish]; Acamprosatum [INN-Latin]; Aotal (TN); Campral (TN); N-Acetylhomotaurine; 3-(Acetylamino)propanesulphonic acid; 3-Acetamido-1-propanesulfonic acid; 3-acetamidopropane-1-sulfonic acid
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Approved [537176], [542113]
Therapeutic Class
Alcohol Deterrents
Structure
Download
2D MOL

3D MOL
Formula
C5H11NO4S
InChI
InChI=1S/C5H11NO4S/c1-5(7)6-3-2-4-11(8,9)10/h2-4H2,1H3,(H,6,7)(H,8,9,10)
InChIKey
AFCGFAGUEYAMAO-UHFFFAOYSA-N
CAS Number
CAS 77337-76-9
PubChem Compound ID
71158
PubChem Substance ID
8194463, 15120629, 43127539, 46506657, 50021914, 51091400, 56464352, 57318038, 75557048, 103810289, 104349795, 117362127, 117633800, 124955684, 125691474, 127397498, 131327164, 132554646, 134224179, 134338136, 135027346, 137002470, 141750083, 160964004, 162912604, 175267284, 178103683, 179151136, 223536069, 226426881, 241137131, 243433170, 250136754
ChEBI ID
ChEBI:51041
SuperDrug ATC ID
N07BB03
SuperDrug CAS ID
cas=077337769
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Agonist [537464]
References
Ref 537176The effects of acamprosate on alcohol-cue reactivity and alcohol priming in dependent patients: a randomized controlled trial. Psychopharmacology (Berl). 2009 Jul;205(1):53-62. Epub 2009 Mar 25.
Ref 542113(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7106).
Ref 537464Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. Addict Biol. 2009 Jul;14(3):328-37.

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