Drug General Information
Drug ID	D0GG2J
Former ID	DNC010902
Drug Name	1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530918]
Structure		Download 2D MOL 3D MOL
Formula	C19H20F4N2O
PubChem Compound ID	46890492
Target and Pathway
Target(s)	Potassium voltage-gated channel subfamily H member 2	Target Info	Inhibitor	[530918]
	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[530918]
	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[530918]
KEGG Pathway	Serotonergic synapse
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Voltage gated Potassium channelsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	SIDS Susceptibility Pathways
	Hematopoietic Stem Cell Differentiation
	Potassium ChannelsWP727:Monoamine Transport
	NRF2 pathway
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP727:Monoamine Transport
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530918	Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. Epub 2010 Apr 18.Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Ref 530918	Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. Epub 2010 Apr 18.Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.

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