Drug Information

Drug General Information
Drug ID
D0GR0T
Former ID
DAP001137
Drug Name
Methadyl Acetate
Synonyms
ALPHACETYLMETHADOL; Acemethadone; Acetilmetadol; Acetylmethadol; Acetylmethadolum; Amidolacetate; Levamethadyl; Acetilmetadol [INN-Spanish]; Acetylmethadol (INN); Acetylmethadolum [INN-Latin]; Methadyl acetate (USAN); Methadyl acetate [USAN:BAN]; N-LAMM; Race-Acetylmethadol; [6-(dimethylamino)-4,4-diphenylheptan-3-yl] acetate; Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester); Benzeneethanol, .beta.-[2-(dimethylamino)propyl]-.alpha.-ethyl-.beta.-phenyl-, acetate; (R,S)-4-Dimethylamino-1-ethyl-2,2-diphenylpentyl acetat; 1-Ethyl-4-dimethylamino-2,2-diphenylpentylacetat; 3-Acetoxy-6-dimethylamino-4,4-diphenylheptane; 4-(Dimethylamino)-1-ethyl-2,2-diphenylpentyl acetate; 6-(Dimethylamino)-4,4-Diphenyl-3-Heptanol Acetate; 6-(Dimethylamino)-4,4-diphenyl-3-heptanol acetate (ester)
Drug Type
Small molecular drug
Indication Opiate dependence [ICD9: 304; ICD10:F11] Approved [538543]
Therapeutic Class
Narcotics
Structure
Download
2D MOL

3D MOL
Formula
C23H31NO2
Canonical SMILES
CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
InChI
1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
InChIKey
XBMIVRRWGCYBTQ-UHFFFAOYSA-N
CAS Number
CAS 509-74-0
PubChem Compound ID
10517
PubChem Substance ID
6154503, 8157599, 10510574, 15496824, 29229004, 46505532, 47206706, 48416233, 49975473, 49975474, 49975475, 49975476, 49975477, 50064825, 57326275, 77992955, 85209477, 103429509, 103936864, 104323515, 125823202, 126408779, 126422751, 126454731, 129665034, 134338382, 134977599, 137016661, 138621358, 160964700, 179226245, 198970365, 198993294, 225077631, 226491594, 241063489, 249934655
SuperDrug ATC ID
N07BC03
SuperDrug CAS ID
cas=001477403
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [537795]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 538543FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020315.
Ref 537795Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9.

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