Drug General Information
Drug ID
D0GR5L
Former ID
DNC003681
Drug Name
AL-43
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526567]
Structure
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2D MOL

3D MOL

Formula
C23H25NO2
Canonical SMILES
CC1=CC(NC2=C1C3=C(C=C2)C4=C(C=CC=C4OC)OC3CC=C)(C)C
InChI
1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
InChIKey
CZSDJYXNNJQXBB-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Inhibitor [527002]
mRNA of androgen receptor Target Info Inhibitor [526567]
Progesterone receptor Target Info Inhibitor [526567]
Mineralocorticoid receptor Target Info Inhibitor [526567]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04114:Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04960:Aldosterone-regulated sodium reabsorption
NetPath Pathway IL2 Signaling Pathway
TCR Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networkanthraxpathway:Cellular roles of Anthrax toxin
PathWhiz Pathway Kidney Function
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1251985:Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP34:Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP554:ACE Inhibitor Pathway
References
Ref 526567J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Ref 526567J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Ref 527002Bioorg Med Chem Lett. 2004 Apr 5;14(7):1721-7.Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.

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