Drug Information

Drug General Information
Drug ID
D0H0KB
Former ID
DAP000527
Drug Name
Riluzole
Synonyms
Rilutek; Riluzol; Riluzolum; Riluzole HCl; RP 54274; ALBB-006046; BF-37; PK-26124; R-116; RP-54274; Rilutek (TN); Riluzol [INN-Spanish]; Riluzole [USAN:INN]; Riluzolum [INN-Latin]; ZERO/001785; Amino-2 trifluoromethoxy-6 benzothiazole; Amino-2 trifluoromethoxy-6 benzothiazole [French]; Riluzole (JAN/USAN/INN); PK-26124, RP-54274, Rilutek, Riluzole; 2-Amino-6-(trifluoromethoxy)-benzothiazole; 2-Amino-6-(trifluoromethoxy)benzothiazole; 2-Amino-6-trifluoro-methoxybenzothiazole; 2-amino-6-(trifluoromethoxy)-1,3-benzothiazole; 2-amino-6-(trifluoromethoxy)benzo[d]thiazole; 2-amino-6-(trifluoromethoxyl)benzothiazole; 2-amino-6-trifluoromethoxybenzothiazole; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-Trifluoromethoxy-benzothiazol-2-ylamine; 6-trifluoromethoxybenzothiazole-2-yl-amine
Drug Type
Small molecular drug
Indication Amyotrophic lateral sclerosis [ICD9: 335.2; ICD10:G12.2] Approved [536648], [539472]
Therapeutic Class
Anticonvulsants
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C8H5F3N2OS
InChI
InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChIKey
FTALBRSUTCGOEG-UHFFFAOYSA-N
CAS Number
CAS 1744-22-5
PubChem Compound ID
5070
PubChem Substance ID
10139, 855844, 866566, 3158794, 7379879, 7735262, 7847840, 7980518, 8153119, 11111722, 11111723, 11113346, 11120296, 11120784, 11121272, 11466195, 11467315, 11484335, 11485690, 11488366, 12013649, 14773880, 17405620, 24278006, 26679689, 26751529, 29224139, 46508094, 47440015, 47515108, 47588789, 47810535, 47810536, 48034873, 48334245, 49698375, 49890627, 50100339, 50104104, 50104105, 53778170, 57322593, 57566695, 57641351, 74971764, 85089205, 85171908, 85231207, 85787918, 85788320
SuperDrug ATC ID
N07XX02
SuperDrug CAS ID
cas=001744225
Target and Pathway
Target(s) Voltage-gated sodium channel Target Info Blocker [535611]
References
Ref 536648Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
Ref 539472(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2326).
Ref 535611Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177-90.

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