Drug Information

Drug General Information
Drug ID
D0H2WQ
Former ID
DNC005427
Drug Name
QUINPIROLE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539287]
Structure
Download
2D MOL

3D MOL
Formula
C13H21N3
InChI
InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
InChIKey
FTSUPYGMFAPCFZ-ZWNOBZJWSA-N
PubChem Compound ID
54562
PubChem Substance ID
7979642, 8183700, 11111699, 11111700, 11112870, 11113890, 11467121, 11468241, 11486789, 14749084, 14822656, 34718542, 47217011, 47589200, 47662524, 48185202, 48185203, 48259472, 48334737, 48334738, 49699323, 50030315, 50490234, 53789374, 57313626, 84970652, 85788346, 85788801, 90341178, 90341722, 90342389, 92308913, 103543557, 103930000, 104094265, 104171332, 104305244, 118842217, 124750152, 124882692, 124882695, 131328223, 134342632, 134392947, 135013177, 135060312, 135650874, 136350737, 139699431, 140359097
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [530429]
D(2) dopamine receptor Target Info Inhibitor [534764]
D(4) dopamine receptor Target Info Inhibitor [527714]
Dopamine D1 receptor Target Info Inhibitor [527714]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
References
Ref 539287(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2).
Ref 527714J Med Chem. 2005 Sep 8;48(18):5771-9.Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Ref 530429J Med Chem. 2009 Nov 12;52(21):6860-70.1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.
Ref 534764J Med Chem. 1998 Dec 3;41(25):4933-8.N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.

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