Drug Information

Drug General Information
Drug ID
D0H3HM
Former ID
DAP000076
Drug Name
Aripiprazole
Synonyms
Abilify; Abilitat; Aripiprazol; Aripiprazolum; Aripirazole; Arpizol; Asprito; Discmelt; Pripiprazole; Abilify Discmelt; Aripiprazole [USAN]; Otsuka brand of aripiprazole; OPC 14597; OPC 31; Opc 14597; ALKS-9070; Abilify (TN); BMS-337039; Bristol-Myers Squibb brand of aripiprazole; Discmelt (TN); KS-1030; OPC-14597; OPC-31; S06-0010; Aripiprazole (JAN/USAN/INN); 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Approved [537632], [540346]
Therapeutic Class
Antipsychotic Agents
Company
Bristol-Myers Squibb; Otsuka Pharmaceutical Co., Ltd
Structure
Download
2D MOL

3D MOL
Formula
C23H27Cl2N3O2
InChI
InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChIKey
CEUORZQYGODEFX-UHFFFAOYSA-N
CAS Number
CAS 129722-12-9
PubChem Compound ID
60795
PubChem Substance ID
582954, 7848227, 7978512, 8187059, 11528738, 12014488, 14759758, 15103350, 25819894, 26719891, 29215485, 29215486, 43118141, 46386763, 46505745, 49658671, 49666283, 49666418, 49681659, 49830718, 57314118, 77392862, 81042514, 81065479, 81092781, 85202210, 85209988, 89736075, 92307952, 92308408, 92308936, 92713933, 103307946, 104021727, 104321668, 117470150, 117868935, 118048569, 124365869, 124658892, 124799564, 125001911, 125339803, 126525334, 126592371, 126624438, 126655782, 126669992, 126728368, 127275956
ChEBI ID
ChEBI:31236
SuperDrug ATC ID
N05AX12
SuperDrug CAS ID
cas=129722129
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [536421]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 537632Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder. Psychopharmacology (Berl). 2009 Jul 30.
Ref 540346(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 34).
Ref 536421Aripiprazole acts as a selective dopamine D2 receptor partial agonist. Expert Opin Investig Drugs. 2007 Jun;16(6):771-5.

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