Drug Information

Drug General Information
Drug ID
D0H4NK
Former ID
DIB018514
Drug Name
1-phenylbiguanide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539434]
Structure
Download
2D MOL
Formula
C8H11N5
InChI
InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)
InChIKey
CUQCMXFWIMOWRP-UHFFFAOYSA-N
PubChem Compound ID
4780
PubChem Substance ID
625012, 3137083, 3286785, 5292419, 5360933, 8150149, 10502442, 10990284, 11111589, 11113825, 11335457, 11335924, 11360696, 11361163, 11363366, 11364354, 11364771, 11365928, 11366916, 11367333, 11368490, 11369478, 11369895, 11372526, 11372935, 11373694, 11374079, 11375495, 11376652, 11377640, 11378060, 11455248, 11456191, 11461668, 11462135, 11484975, 11489006, 11491419, 11491873, 11492135, 11494286, 11495274, 15147255, 17405545, 24263014, 24850064, 26751999, 29223864, 47291033, 47291034
Target and Pathway
Target(s) 5-HT3AB Target Info Agonist [526116]
5-hydroxytryptamine receptor 3A Target Info Agonist [533742]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 539434(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2284).
Ref 526116Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4.
Ref 533742Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors. J Neurochem. 1995 Jul;65(1):104-10.

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