Drug Information

Drug General Information
Drug ID
D0H5XR
Former ID
DNC008386
Drug Name
YM-348
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539452]
Structure
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2D MOL

3D MOL
Formula
C14H17N3O
InChI
InChI=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14(10)12)8-9(2)15/h4-7,9H,3,8,15H2,1-2H3/t9-/m0/s1
InChIKey
QLOOWOVVZLBYHU-VIFPVBQESA-N
PubChem Compound ID
3045225
PubChem Substance ID
10052656, 36112148, 49691068, 50076763, 57353839, 75392733, 103568659, 111663670, 134345591, 135185226, 135651344, 139972399, 160854540, 162224504, 228141333, 246244139
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [529221]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [529221]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [529221]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539452(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 230).
Ref 529221Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. Epub 2007 Dec 8.Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.

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