Drug Information

Drug General Information
Drug ID
D0H6QU
Former ID
DIB015641
Drug Name
Apomorphine
Synonyms
Apomorphine (intranasal, Parkinson's disease)
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [525056], [540260]
Company
Archimedes Pharma Ltd
Structure
Download
2D MOL

3D MOL
Formula
C17H17NO2
InChI
InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
InChIKey
VMWNQDUVQKEIOC-CYBMUJFWSA-N
PubChem Compound ID
6005
PubChem Substance ID
7978719, 8153735, 11114270, 11466129, 11467249, 11485757, 14823961, 14848260, 24262970, 26752261, 29225019, 46508653, 47216673, 47365074, 47365075, 47662161, 47662162, 47662163, 48110346, 48184887, 48259117, 48415574, 49658769, 49698343, 49871434, 50322702, 51091791, 57323108, 85788349, 85856298, 92308726, 92729815, 93622853, 103167211, 103916308, 104310845, 124887059, 124887060, 126522630, 129497604, 134337595, 134971357, 135304977, 135649950, 137001467, 142333205, 144204518, 160964058, 163667986, 164788060
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [529937]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 525056ClinicalTrials.gov (NCT02339064) Infusion of Apomorphine: Long-term Safety Study. U.S. National Institutes of Health.
Ref 540260(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 33).
Ref 529937Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. Synapse. 2009 May;63(5):378-89.

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