Drug General Information
Drug ID
D0H8XV
Former ID
DNC009877
Drug Name
R-dimethindene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530300]
Structure
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2D MOL

3D MOL

Formula
C20H24N2
Canonical SMILES
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
InChI
1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m0/s1
InChIKey
MVMQESMQSYOVGV-HNNXBMFYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530300]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [530300]
Histamine H1 receptor Target Info Inhibitor [530300]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channelsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
GPCR downstream signaling
References
Ref 530300J Med Chem. 2009 Sep 10;52(17):5307-10.Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.
Ref 530300J Med Chem. 2009 Sep 10;52(17):5307-10.Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

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