Drug General Information
Drug ID	D0H9GQ
Former ID	DCL000780
Drug Name	DOV-216303
Drug Type	Small molecular drug
Indication	Severe mood disorders [ICD9: 296; ICD10:F30-F39]		Discontinued in Phase 2	[536580]
Company	DOV
Structure		Download 2D MOL 3D MOL
Formula	C11H11Cl2N
Canonical SMILES	C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
InChI	1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2
InChIKey	BSMNRYCSBFHEMQ-UHFFFAOYSA-N
PubChem Compound ID	9795276
PubChem Substance ID	15196133, 24105398, 44831292, 79665352, 103585439, 104100081, 127561811, 134339264, 134346265, 137008357, 141074195, 162221510, 162571881, 172913589, 223883233, 226458441, 234991925, 251970167, 252822878
Target and Pathway
Target(s)	Dopamine reuptake	Target Info	Inhibitor	[536580]
	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[536580]
	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[536580]
KEGG Pathway	Serotonergic synapse
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	SIDS Susceptibility Pathways
	NRF2 pathway
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP727:Monoamine Transport
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536580	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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