Drug Information

Drug General Information
Drug ID
D0H9KW
Former ID
DNC002668
Drug Name
Filaminast
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [545618]
Structure
Download
2D MOL

3D MOL
Formula
C15H20N2O4
Canonical SMILES
CC(=NOC(=O)N)C1=CC(=C(C=C1)OC)OC2CCCC2
InChI
1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)/b17-10+
InChIKey
STTRYQAGHGJXJJ-LICLKQGHSA-N
CAS Number
CAS 141184-34-1
PubChem Compound ID
9578243
PubChem Substance ID
7887487, 14751370, 23998140, 44716149, 46506759, 46515096, 47206131, 57373175, 77627239, 103723499, 135170050, 137009718, 137244945, 140136917, 152138144, 160965837, 179149907, 179323165, 198943947, 226453782, 226453783
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [551393]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 545618Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003918)
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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