TTD | Drug: D0HA6Y

Drug General Information
Drug ID	D0HA6Y
Former ID	DIB018129
Drug Name	[11C]SB207145
Synonyms	[11C] SB207145 (PET ligand)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540217]
Structure		Download 2D MOL 3D MOL
Formula	C16H21ClN2O4
InChI	InChI=1S/C16H18ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h8,10H,2-7,9,18H2/i1-1
InChIKey	GZIVVHOGLMLPGS-BJUDXGSMSA-N
PubChem Compound ID	73755034
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Antagonist	[531597]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
Reactome	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540217	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3244).
Ref 531597	Mass dose effects and in vivo affinity in brain PET receptor studies--a study of cerebral 5-HT4 receptor binding with [11C]SB207145. Nucl Med Biol. 2011 Nov;38(8):1085-91.

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Drug Information