Drug Information

Drug General Information
Drug ID
D0HJ9U
Former ID
DIB011472
Drug Name
LAU-0901
Synonyms
PAF receptor antagonist (brain ischemia/ corneal disease), Louisiana State University; Platelet-activating factor receptor antagonist (brain ischemia/ corneal disease), Louisiana State University
Indication Brain ischaemia [ICD9: 435, 437; ICD10:G45.9, I67.8] Investigative [529694], [531839]
Company
Louisiana State University
Structure
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2D MOL

3D MOL
Canonical SMILES
C1(=C(C(C(=C(N1)C)C(=O)OCCOc1ccc(c(c1)Cl)Cl)C)C(=O)OC(C<br />N1CCOCC1)CN1CCOCC1)C.Cl.Cl
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [529694], [531839]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 529694LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. 2008 Dec;214(2):253-8.
Ref 531839Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke. Transl Stroke Res. 2012 Mar;3(1):154-63.
Ref 529694LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. 2008 Dec;214(2):253-8.
Ref 531839Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke. Transl Stroke Res. 2012 Mar;3(1):154-63.

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