Drug General Information
Drug ID	D0I0GM
Former ID	DIB004728
Drug Name	Daxalipram
Synonyms	Mesopram; SH-636; ZK-117137; PDE 4 inhibitor (multiple sclerosis), Schering AG
Indication	Multiple scierosis [ICD9: 340; ICD10:G35]		Discontinued in Phase 2	[547377]
Company	Bayer Schering Pharma AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=O)O[C@](c2cc(c(cc2)OC)OCCC)(CN1)C
CAS Number	CAS 189940-24-7
Target and Pathway
Target(s)	Type IV phosphodiesterase	Target Info	Inhibitor	[532832]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4B	Target Info	Inhibitor	[532832]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4A	Target Info	Inhibitor	[532832]
KEGG Pathway	Purine metabolism
	cAMP signaling pathway
	Morphine addictionhsa00230:Purine metabolism
	Morphine addiction
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
PathWhiz Pathway	Purine Metabolism
Reactome	DARPP-32 events
	G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
	G alpha (s) signalling events
WikiPathways	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	TSH signaling pathwayWP35:G Protein Signaling Pathways
	Nuclear Receptors Meta-Pathway
	Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 547377	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015672)
Ref 532832	Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129.

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