Drug General Information
Drug ID	D0I0WP
Former ID	DNC009407
Drug Name	4-(methyl(4-phenylthiazol-2-yl)amino)phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529388]
Structure		Download 2D MOL 3D MOL
Formula	C16H14N2OS
Canonical SMILES	CN(C1=CC=C(C=C1)O)C2=NC(=CS2)C3=CC=CC=C3
InChI	1S/C16H14N2OS/c1-18(13-7-9-14(19)10-8-13)16-17-15(11-20-16)12-5-3-2-4-6-12/h2-11,19H,1H3
InChIKey	XDKOSPFALAXPJO-UHFFFAOYSA-N
PubChem Compound ID	649391
Target and Pathway
Target(s)	Collagenase 3	Target Info	Inhibitor	[529388]
NetPath Pathway	IL1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
WikiPathways	Endochondral Ossification
	Activation of Matrix Metalloproteinases
	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	Matrix Metalloproteinases
References
Ref 529388	Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Ref 529388	Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.

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