Drug General Information
Drug ID	D0I3PG
Former ID	DIB005978
Drug Name	SDZ-CPI-975
Synonyms	CPT inhibitors, Sandoz; Carnitine palmitoyl transferase I inhbitors, Sandoz; SDZ-267-894
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Discontinued in Phase 1	[545960]
Company	Sandoz Research Institute
Structure		Download 2D MOL 3D MOL
Canonical SMILES	P(=O)(O[C@H](CC(=O)O)[N+](C)(C)C)([O-])OCCCCCCCCCCCCCC
CAS Number	CAS 157244-53-6
Target and Pathway
Target(s)	Carnitine O-palmitoyltransferase I	Target Info	Inhibitor	[534566]
KEGG Pathway	Fatty acid degradation
	Fatty acid metabolism
	PPAR signaling pathway
	AMPK signaling pathway
	Adipocytokine signaling pathway
	Glucagon signaling pathway
PathWhiz Pathway	Fatty acid Metabolism
Reactome	RORA activates gene expression
	PPARA activates gene expression
	Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways	SIDS Susceptibility Pathways
	Mitochondrial LC-Fatty Acid Beta-Oxidation
	Nuclear Receptors Meta-Pathway
	PPAR Alpha Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Circadian Clock
	Fatty Acid Beta Oxidation
	AMPK Signaling
References
Ref 545960	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005522)
Ref 534566	Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. Am J Physiol. 1998 Feb;274(2 Pt 2):R524-8.

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