Drug Information

Drug General Information
Drug ID
D0I3XA
Former ID
DNC002338
Drug Name
Ciproxifan
Drug Type
Small molecular drug
Indication Dementia; Obesity [ICD9: 290-294, 278; ICD10:F01-F07, E66] Investigative [538780]
Structure
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2D MOL

3D MOL
Formula
C16H18N2O2
InChI
InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)
InChIKey
ACQBHJXEAYTHCY-UHFFFAOYSA-N
CAS Number
CAS 184025-19-2
PubChem Compound ID
6422124
PubChem Substance ID
14774960, 29217532, 29217533, 43016263, 47434879, 47583760, 50070539, 50071174, 52113953, 53790071, 57298923, 57304380, 57366836, 85209025, 90341100, 103177393, 114520252, 123051072, 127387036, 131549292, 135323023, 135650102, 137007869, 137156933, 144235387, 152258581, 160647417, 162205198, 163641900, 177749578, 186014464, 189024876, 198972741, 198993150, 225089285, 229360424, 242060244, 249979315, 251883549
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Antagonist [536039]
5-Hydroxytryptamine 3 receptor Target Info Antagonist [536039]
Histamine H3 receptor Target Info Antagonist [536039]
Alpha-2C adrenergic receptor Target Info Antagonist [536039]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390650:Histamine receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 538780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1265).
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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