Drug General Information
Drug ID	D0I4RK
Former ID	DNC009952
Drug Name	N-hydroxy-2,2-diphenylpropanamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530327]
Structure		Download 2D MOL 3D MOL
Formula	C15H15NO2
Canonical SMILES	CC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)NO
InChI	1S/C15H15NO2/c1-15(14(17)16-18,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,18H,1H3,(H,16,17)
InChIKey	LDAQHFMKFUATRE-UHFFFAOYSA-N
PubChem Compound ID	45482660
Target and Pathway
Target(s)	Histone deacetylase	Target Info	Inhibitor	[530327]
	Histone deacetylase 4	Target Info	Inhibitor	[530327]
KEGG Pathway	Alcoholism
	Epstein-Barr virus infection
	Viral carcinogenesis
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class III
	Signaling events mediated by HDAC Class I
	Sumoylation by RanBP2 regulates transcriptional repression
	Validated nuclear estrogen receptor alpha network
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
WikiPathways	Endochondral Ossification
	Cardiac Hypertrophic Response
	Neural Crest Differentiation
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	TarBasePathway
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 530327	Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. Epub 2009 Aug 7.Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Ref 530327	Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. Epub 2009 Aug 7.Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

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