Drug General Information
Drug ID	D0I4ZN
Former ID	DIB012539
Drug Name	GSK2879552
Indication	Small-cell lung cancer [ICD9: 162.9; ICD10:C33-C34]		Phase 1	[524597]
Company	Glaxosmithkline
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Lysine specific histone demethylase 1	Target Info	Inhibitor	[533290]
Pathway Interaction Database	Notch signaling pathway
	Coregulation of Androgen receptor activity
	Notch-mediated HES/HEY network
Reactome	HDACs deacetylate histones
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Factors involved in megakaryocyte development and platelet production
	Androgen receptor signaling pathway
References
Ref 524597	ClinicalTrials.gov (NCT02034123) Investigation of GSK2879552 in Subjects With Relapsed/Refractory Small Cell Lung Carcinoma. U.S. National Institutes of Health.
Ref 533290	A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.

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