Drug General Information
Drug ID	D0I6MA
Former ID	DIB019704
Drug Name	DC-EBIO
Synonyms	dichloro-EBIO
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539471]
Structure		Download 2D MOL
Formula	C9H8Cl2N2O
InChI	InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)
InChIKey	LKHRMULASXZCLG-UHFFFAOYSA-N
PubChem Compound ID	656765
PubChem Substance ID	854089, 6213728, 9268126, 11111113, 11114078, 14749342, 17404997, 24278396, 47349357, 50104848, 50104849, 53777540, 56463461, 57408420, 78240964, 85231020, 85789028, 90341651, 91703976, 92303913, 93578450, 113528213, 121361254, 123088606, 124749712, 124801469, 124879972, 124879973, 128501477, 135650163, 137248073, 162022940, 162247819, 163133887, 163563824, 163564388, 163724383, 163737669, 164212502, 178125684, 219402187, 223442446, 223519285, 226913755, 241110095, 241182418
Target and Pathway
Target(s)	KCa3.1	Target Info	Activator	[525956]
	KCa2.2	Target Info	Activator	[527812]
	KCa2.3	Target Info	Activator	[528912]
References
Ref 539471	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2324).
Ref 525956	Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.
Ref 527812	Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. J Biol Chem. 2005 Dec16;280(50):41404-11. Epub 2005 Oct 20.
Ref 528912	Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57.

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