Drug General Information
Drug ID	D0I6UU
Former ID	DIB003540
Drug Name	UK-74505
Drug Type	Small molecular drug
Indication	Septic shock [ICD9: 785.52; ICD10:A41.9]		Discontinued in Phase 2	[544958]
Company	Pfizer Ltd
Structure		Download 2D MOL 3D MOL
Formula	C34H29ClN6O3
Canonical SMILES	C1(=C(NC(=C(C1c1c(Cl)cccc1)C(=O)Nc1ncccc1)C)c1ccc(n2c(n<br />c3c2ccnc3)C)cc1)C(=O)OCC
CAS Number	CAS 122956-68-7
PubChem Compound ID	129796
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Antagonist	[533761]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544958	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001719)
Ref 533761	Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin. Br J Pharmacol. 1994 Oct;113(2):513-21.

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