Drug General Information
Drug ID	D0I9NH
Former ID	DNC006482
Drug Name	5-hydroxy-2-(4-aminophenyl)benzofuran
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528159]
Structure		Download 2D MOL 3D MOL
Formula	C14H11NO2
Canonical SMILES	C1=CC(=CC=C1C2=CC3=C(O2)C=CC(=C3)O)N
InChI	1S/C14H11NO2/c15-11-3-1-9(2-4-11)14-8-10-7-12(16)5-6-13(10)17-14/h1-8,16H,15H2
InChIKey	JDGXRZSZWVUFMN-UHFFFAOYSA-N
PubChem Compound ID	11499570
Target and Pathway
Target(s)	Amyloid beta A4 protein	Target Info	Inhibitor	[528159]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
Reactome	Nuclear signaling by ERBB4
	Degradation of the extracellular matrix
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Alzheimers Disease
	Signalling by NGF
References
Ref 528159	J Med Chem. 2006 May 4;49(9):2725-30.Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.
Ref 528159	J Med Chem. 2006 May 4;49(9):2725-30.Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.

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