Drug Information

Drug General Information
Drug ID
D0IP9V
Former ID
DNC008508
Drug Name
PH-709829
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529479]
Structure
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2D MOL

3D MOL
Formula
C15H17N3O2
Canonical SMILES
C1CN2CC1CC(C2)NC(=O)C3=NC=C4C(=C3)C=CO4
InChI
1S/C15H17N3O2/c19-15(13-6-11-2-4-20-14(11)7-16-13)17-12-5-10-1-3-18(8-10)9-12/h2,4,6-7,10,12H,1,3,5,8-9H2,(H,17,19)/t10-,12-/m1/s1
InChIKey
PTGWFYYEAUFEAS-ZYHUDNBSSA-N
PubChem Compound ID
10107234
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Inhibitor [529479]
Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Inhibitor [529479]
KEGG Pathway Serotonergic synapsehsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Ligand-gated ion channel transportR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 529479Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. Epub 2008 May 1.Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
Ref 529479Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. Epub 2008 May 1.Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.

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