Drug Information

Drug General Information
Drug ID
D0IR6U
Former ID
DIB020094
Drug Name
CMP-6
Synonyms
CMP-6
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541258]
Structure
Download
2D MOL
Formula
C18H16FN3O
InChI
InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChIKey
VNDWQCSOSCCWIP-UHFFFAOYSA-N
PubChem Compound ID
5494425
PubChem Substance ID
8149086, 10317686, 10318987, 10318988, 11114603, 14894341, 17422859, 26758981, 26758982, 39475612, 46391336, 46393871, 46505719, 50726742, 53837812, 56464635, 56468342, 57364805, 85261411, 92765175, 93578179, 93578181, 99302706, 99381271, 103186466, 103905610, 121168749, 135324603, 135685342, 135685343, 135685359, 136367880, 137821865, 142592967, 143499791, 144116195, 152234892, 160844988, 160967700, 161003590, 162168883, 162205080, 163124151, 163620792, 163686118, 163687865, 163687866, 163781232, 172096384, 174006716
Target and Pathway
Target(s) Tyrosine-protein kinase JAK2 Target Info Inhibitor [526307]
Tyrosine-protein kinase JAK3 Target Info Inhibitor [526307]
TYK2 Target Info Inhibitor [529213]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Cholinergic synapse
Prolactin signaling pathway
Adipocytokine signaling pathway
Leishmaniasis
Toxoplasmosis
Tuberculosis
Measles
Influenza A
Herpes simplex infectionhsa04062:Chemokine signaling pathway
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiencyhsa04380:Osteoclast differentiation
Hepatitis C
Herpes simplex infection
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
PI3 kinase pathway
CCKR signaling map STP00036:Interleukin signaling pathway
Pathway Interaction Database Endothelins
ErbB4 signaling events
GMCSF-mediated signaling events
IL4-mediated signaling events
IL27-mediated signaling events
Signaling events mediated by PTP1B
IL12-mediated signaling events
S1P3 pathway
SHP2 signaling
CXCR4-mediated signaling events
IL5-mediated signaling events
IFN-gamma pathway
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
IL23-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Notch-mediated HES/HEY networkil4_2pathway:IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5il27pathway:IL27-mediated signaling events
Reactome Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
GPVI-mediated activation cascade
Prolactin receptor signaling
RMTs methylate histone arginines
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
Interleukin-7 signaling
Interleukin-2 signaling
Interleukin receptor SHC signalingR-HSA-1059683:Interleukin-6 signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Type II interferon signaling (IFNG)
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Interleukin-2 signaling
Signaling by SCF-KIT
Prolactin receptor signaling
Growth hormone receptor signaling
JAK/STAT
BDNF signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TSLP Signaling Pathway
IL17 signaling pathway
Leptin signaling pathway
TSH signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Interferon gamma signaling
Factors involved in megakaryocyte development and platelet production
IL-5 Signaling PathwayWP49:IL-2 Signaling Pathway
Interleukin-7 signaling
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signalingWP585:Interferon type I signaling pathways
Type III interferon signaling
Interferon alpha/beta signaling
References
Ref 541258(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5992).
Ref 526307Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23.
Ref 529213Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

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