Drug Information

Drug General Information
Drug ID
D0IX7S
Former ID
DNC000917
Drug Name
MDL 100,453
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534895]
Structure
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2D MOL

3D MOL
Formula
C5H10NO6P
Canonical SMILES
C(C(C(=O)O)N)C(=O)CP(=O)(O)O
InChI
1S/C5H10NO6P/c6-4(5(8)9)1-3(7)2-13(10,11)12/h4H,1-2,6H2,(H,8,9)(H2,10,11,12)/t4-/m1/s1
InChIKey
OLCWOBHEVRCMLO-SCSAIBSYSA-N
CAS Number
CAS 129938-34-7
PubChem Compound ID
3035602
PubChem Substance ID
10048406, 15220214, 15244639, 36079032, 79250632, 103294548, 103923639, 111639336, 128824722, 135081341, 226554172
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Antagonist [534895]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathway
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers Disease
References
Ref 534895Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther. 1999 Sep;290(3):1034-40.
Ref 534895Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther. 1999 Sep;290(3):1034-40.

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