Drug Information

Drug General Information
Drug ID
D0J1PJ
Former ID
DNC001481
Drug Name
U50,488H
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539022]
Structure
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2D MOL

3D MOL
Formula
C19H26Cl2N2O
InChI
InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
InChIKey
VQLPLYSROCPWFF-QZTJIDSGSA-N
CAS Number
CAS 83913-06-8
PubChem Compound ID
3036289
PubChem Substance ID
13960, 7980053, 10744781, 11111942, 11111943, 14901839, 26756547, 36104498, 47574471, 49878458, 53790425, 79745843, 103914903, 111640993, 123099351, 124750360, 129512381, 131329802, 134339440, 135651290, 137133073, 163425981, 179150904, 226668693
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [534904], [535113]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539022(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1652).
Ref 534904Effects of kappa- and mu-opioid receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opioid receptor. Eur J Pharmacol. 1999 Aug 27;379(2-3):191-8.
Ref 535113The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat. Behav Brain Res. 2001 May;120(2):137-46.

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