Drug General Information
Drug ID	D0J3EZ
Former ID	DNC012250
Drug Name	6-Nitro-1,4-dihydro-quinoxaline-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534504]
Structure		Download 2D MOL 3D MOL
Formula	C8H5N3O4
Canonical SMILES	C1=CC2=C(C=C1[N+](=O)[O-])NC(=O)C(=O)N2
InChI	1S/C8H5N3O4/c12-7-8(13)10-6-3-4(11(14)15)1-2-5(6)9-7/h1-3H,(H,9,12)(H,10,13)
InChIKey	RYMLSFWVYNAKAR-UHFFFAOYSA-N
PubChem Compound ID	4038142
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[534504]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[534504]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[534504]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Huntington's disease
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathway
Reactome	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 534504	J Med Chem. 1997 Oct 24;40(22):3679-86.5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.
Ref 534504	J Med Chem. 1997 Oct 24;40(22):3679-86.5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.

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