Drug Information

Drug General Information
Drug ID
D0J5GT
Former ID
DNC009742
Drug Name
ZANKIREN
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [545082]
Structure
Download
2D MOL

3D MOL
Formula
C35H55N5O6S2
Canonical SMILES
CC(C)CC(C(C(CC1CCCCC1)NC(=O)C(CC2=CSC=N2)NC(=O)C(CC3=CC<br />=CC=C3)CS(=O)(=O)N4CCN(CC4)C)O)O
InChI
1S/C35H55N5O6S2/c1-25(2)18-32(41)33(42)30(20-27-12-8-5-9-13-27)37-35(44)31(21-29-22-47-24-36-29)38-34(43)28(19-26-10-6-4-7-11-26)23-48(45,46)40-16-14-39(3)15-17-40/h4,6-7,10-11,22,24-25,27-28,30-33,41-42H,5,8-9,12-21,23H2,1-3H3,(H,37,44)(H,38,43)/t28-,30+,31+,32+,33-/m1/s1
InChIKey
YFDSDRDMDDGDFC-HOQQKOLYSA-N
PubChem Compound ID
3086652
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [530066]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 545082Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002065)
Ref 530066J Med Chem. 2009 Jun 25;52(12):3689-702.Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.

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