Drug Information

Drug General Information
Drug ID
D0J6JT
Former ID
DIB020312
Drug Name
m-chlorophenylpiperazine
Synonyms
1-(m-chlorophenyl)piperazine; meta chlorophenyl piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538897]
Structure
Download
2D MOL
Formula
C10H13ClN2
InChI
InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
InChIKey
VHFVKMTVMIZMIK-UHFFFAOYSA-N
PubChem Compound ID
1355
PubChem Substance ID
13903, 101536, 3134490, 5654977, 8151106, 11110958, 11113750, 15487730, 24439696, 26744257, 26751928, 29200406, 32928407, 47440463, 47959960, 47959961, 48110652, 48334707, 50008640, 50104608, 53788779, 53792953, 57320881, 57566619, 58033993, 79793345, 85208880, 85261770, 85788310, 87631290, 92091370, 92712037, 103169070, 103904029, 103916282, 104171132, 104297497, 104649718, 117458520, 118082316, 124749567, 124879663, 124879664, 124879665, 125323619, 125355774, 126581139, 126607690, 126614717, 126630282
Target and Pathway
Target(s) 5-hydroxytryptamine 1E receptor Target Info Agonist [526943]
5-hydroxytryptamine 2C receptor Target Info Agonist [526921]
5-hydroxytryptamine 7 receptor Target Info Agonist [534019]
5-hydroxytryptamine 6 receptor Target Info Agonist [533689]
5-hydroxytryptamine 2A receptor Target Info Agonist [534830]
5-hydroxytryptamine 2B receptor Target Info Agonist [534042]
5-hydroxytryptamine 1D receptor Target Info Antagonist [528072]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04014:Ras signaling pathway
Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 538897(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 142).
Ref 526921Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur J Pharmacol. 2004 Jan 1;483(1):37-43.
Ref 526943Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39.
Ref 528072Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8.
Ref 533689Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7.
Ref 534019Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4.
Ref 534042Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26.
Ref 534830Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6.

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