Drug General Information
Drug ID
D0J7GF
Former ID
DNC011964
Drug Name
Benzyl-(2-phenyl-quinazolin-4-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533684]
Structure
Download
2D MOL

3D MOL

Formula
C21H17N3
Canonical SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4
InChI
1S/C21H17N3/c1-3-9-16(10-4-1)15-22-21-18-13-7-8-14-19(18)23-20(24-21)17-11-5-2-6-12-17/h1-14H,15H2,(H,22,23,24)
InChIKey
WXCHSHPXEPXKFN-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [533684]
Sodium-dependent dopamine transporter Target Info Inhibitor [535513]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [533684]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa04728:Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP727:Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP35:G Protein Signaling Pathways
References
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Ref 535513Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8.

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