Drug Information

Drug General Information
Drug ID
D0J8ZA
Former ID
DAP000955
Drug Name
Quinethazone
Synonyms
Aquamox; Chinetazone; Chinethazone; Chinethazonum; Hydromox; Idrokin; Quinetazona; Quinethazon; Quinethazonum; Chinetazone[DCIT]; CL 36010; Hydromox (TN); Quinetazona [INN-Spanish]; Quinethazone (aquamox); Quinethazonum [INN-Latin]; Quinethazone (JAN/INN); Quinethazone [INN:BAN:JAN]; 2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxochinazolin-6-sulfonamid; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline; 7-Chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone; 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
Drug Type
Small molecular drug
Indication Hypertension; Congestive heart failure [ICD9: 401, 428; ICD10:I10-I16, I50] Approved [538464], [542309], [551871]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H12ClN3O3S
InChI
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
InChIKey
AGMMTXLNIQSRCG-UHFFFAOYSA-N
CAS Number
CAS 73-49-4
PubChem Compound ID
6307
PubChem Substance ID
9549, 7784537, 7847527, 8153978, 11467078, 11468198, 11486646, 14800035, 29225299, 46507280, 47499748, 48019132, 48169593, 48243604, 48416507, 48424029, 49699269, 49855752, 56413186, 56463176, 57323335, 77472399, 85787548, 92125946, 103565930, 103870598, 103914667, 104311682, 121363617, 124801002, 125823752, 127403478, 134338229, 134972947, 137156434, 144076234, 144203917, 160964622, 170465167, 175611017, 176262168, 178103863, 178126126, 179149414, 223440822, 226642054, 250104410
SuperDrug ATC ID
C03BA02
SuperDrug CAS ID
cas=000073494
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [536672]
References
Ref 538464FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 013264.
Ref 542309(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7289).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536672Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73. Epub 2008 Mar 20.

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