Drug Information

Drug General Information
Drug ID
D0JD4C
Former ID
DNC005980
Drug Name
L-454560
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531102]
Structure
Download
2D MOL

3D MOL
Formula
C31H29N3O5S2
Canonical SMILES
CC1=NOC(=N1)C(=CC2=CC=CC(=C2)C3=C4C(=CC(=C3)C(C)(C)S(=O<br />)(=O)C)C=CC=N4)C5=CC=C(C=C5)S(=O)(=O)C
InChI
1S/C31H29N3O5S2/c1-20-33-30(39-34-20)28(22-11-13-26(14-12-22)40(4,35)36)17-21-8-6-9-23(16-21)27-19-25(31(2,3)41(5,37)38)18-24-10-7-15-32-29(24)27/h6-19H,1-5H3/b28-17+
InChIKey
YYGZHVJDHMMABU-OGLMXYFKSA-N
PubChem Compound ID
9853498
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [531102]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [531102]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [531102]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 531102Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. Epub 2010 Jul 21.The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
Ref 531102Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. Epub 2010 Jul 21.The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.