Drug Information

Drug General Information
Drug ID
D0JH9J
Former ID
DNC005978
Drug Name
6-biphenyl-2-yl-2-morpholin-4-yl-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Structure
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2D MOL

3D MOL
Formula
C25H21NO3
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)C4=CC=CC=C4C5=CC=CC=C<br />5
InChI
1S/C25H21NO3/c27-23-17-25(26-12-14-28-15-13-26)29-24-11-10-19(16-22(23)24)21-9-5-4-8-20(21)18-6-2-1-3-7-18/h1-11,16-17H,12-15H2
InChIKey
RYQNUEMYQYWYOR-UHFFFAOYSA-N
PubChem Compound ID
11603381
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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