Drug Information

Drug General Information
Drug ID
D0JY2K
Former ID
DIB014038
Drug Name
NS-1643
Synonyms
HERG potassium channel openers (arrhythmia); NS-1643; NS-3623; NS-373; HERG potassium channel openers (arrhythmia), NeuroSearch; I(Kr) agonists (arrhythmia), NeuroSearch; Rapid delayed-rectifier current activators (acquired long QT syndrome), NeruoSearch
Drug Type
Small molecular drug
Indication Heart arrhythmia [ICD10:I47-I49] Investigative [542638]
Company
NeuroSearch A/S
Structure
Download
2D MOL

3D MOL
Formula
C15H10F6N2O3
InChI
InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
InChIKey
NJFVQMRYJZHGME-UHFFFAOYSA-N
CAS Number
CAS 343630-41-1
PubChem Compound ID
10177784
PubChem Substance ID
15173214, 22573400, 24897438, 29217596, 40267360, 57374332, 78106763, 135650743, 135698605, 137034138, 160839545, 162119371, 162248127, 162525235, 163402449, 163846304, 170474670, 170558902, 189614623, 198960277, 204425702, 223370023, 223397698, 223573615, 227670517, 242313646, 248536620, 252156985, 252262372, 252304534, 252553002
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Opener [543879]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 542638(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7660).
Ref 543879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 572).

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