Drug Information

Drug General Information
Drug ID
D0K0YX
Former ID
DNC009966
Drug Name
5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530333]
Structure
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2D MOL

3D MOL
Formula
C18H17NO3
Canonical SMILES
C1=CC(=CC=C1CCC(CC(=O)O)O)C2=CC=C(C=C2)C#N
InChI
1S/C18H17NO3/c19-12-14-3-8-16(9-4-14)15-6-1-13(2-7-15)5-10-17(20)11-18(21)22/h1-4,6-9,17,20H,5,10-11H2,(H,21,22)
InChIKey
YDAZWMGCTBJQEO-UHFFFAOYSA-N
PubChem Compound ID
44626352
Target and Pathway
Target(s) Collagenase 3 Target Info Inhibitor [530333]
MMP-12 Target Info Inhibitor [530333]
NetPath Pathway IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL5 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

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