Drug Information

Drug General Information
Drug ID
D0K4MH
Former ID
DNAP001696
Drug Name
Tapentadol hydrochloride
Drug Type
Small molecular drug
Indication Moderate-to-severe acute pain [ICD9: 338,780; ICD10:R52, G89] Approved [529941]
Company
Ortho-McNell Pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C14H23NO
Canonical SMILES
CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
InChI
1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1
InChIKey
KWTWDQCKEHXFFR-SMDDNHRTSA-N
PubChem Compound ID
9838022
PubChem Substance ID
14892326, 24136893, 44936111, 47207665, 50598570, 57373488, 87692438, 124772162, 126644483, 126666948, 128445985, 135207317, 135693229, 135693230, 136980026, 137147726, 142418252, 144115428, 152090609, 160693267, 160865464, 162012004, 164041986, 172919383, 174527899, 175267498, 175427057, 179150074, 187051780, 210276624, 223519387, 223661873, 224282350, 226489097, 252481185
SuperDrug ATC ID
N02AX06
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Modulator [529941]
Sodium-dependent noradrenaline transporter Target Info Modulator [529941]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

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