Drug General Information
Drug ID	D0K6SM
Former ID	DCL000132
Drug Name	Ilepatril
Indication	Hypertension; Renal failure; Heart failure; Diabetic nephropathy [ICD9: 250, 401, 428, 580-599, 584, 585; ICD10:E08-E13, I10-I16, I50, N00-N29, N17, N18, N19]		Discontinued in Phase 2/3	[536642]
Company	Sanofi-Aventis
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Neutral endopeptidase	Target Info	Modulator	[536642]
	Angiotensin-converting enzyme	Target Info	Modulator	[536642]
KEGG Pathway	Renin-angiotensin system
	Hematopoietic cell lineage
	Protein digestion and absorption
	Alzheimer's diseasehsa04614:Renin-angiotensin system
	Chagas disease (American trypanosomiasis)
	Hypertrophic cardiomyopathy (HCM)
NetPath Pathway	EGFR1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Angiotensin Metabolism
Reactome	Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways	Metabolism of Angiotensinogen to Angiotensins
	Primary Focal Segmental Glomerulosclerosis FSGS
	Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 536642	Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9.
Ref 536642	Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9.

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