Drug General Information
Drug ID	D0K7FT
Former ID	DIB016672
Drug Name	AG-221
Synonyms	AG-221 (IDH2 inhibitor)
Indication	Acute myeloid leukemia [ICD9: 205; ICD10:C92.0]		Phase 1/2	[524966]
Company	Agios pharmaceuticals; celgene
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Isocitrate dehydrogenase (IDH2)	Target Info	Inhibitor	[544463]
KEGG Pathway	Citrate cycle (TCA cycle)
	Glutathione metabolism
	Metabolic pathways
	Biosynthesis of antibiotics
	Carbon metabolism
	2-Oxocarboxylic acid metabolism
	Biosynthesis of amino acids
	Peroxisome
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
WikiPathways	TCA Cycle
	The citric acid (TCA) cycle and respiratory electron transport
References
Ref 524966	ClinicalTrials.gov (NCT02273739) Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation. U.S.National Institutes of Health.
Ref 544463	New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma. Int J Med Sci. 2015; 12(3): 201-213.

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