Drug Information

Drug General Information
Drug ID
D0K7WK
Former ID
DAP000221
Drug Name
Ondansetron
Synonyms
DESMETHYLONDANSETRON; Zofran; Zophren; Zudan; Sandoz ondansetron; ZOFRAN IN PLASTIC CONTAINER; Zofran ODT; GR 38032; GR 38032X; GR38032F; Apo-ondansetron; GR-38032F; Novo-ondansetron; Ondansetron (Zofran); PHL-ondansetron; PMS-ondansetron; Ratio-ondansetron; SN-307; Zofran (TN); Zofran ODT (TN); Ondansetron [USAN:INN:BAN]; Ondansetron (JAN/USP/INN); Ondansetron, (+,-)-Isomer; (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one; 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one; 9-Methyl-3-(2-methyl-imidazol-1-ylmethyl)-1,2,3,9-tetrahydro-carbazol-4-one; 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one; 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
Drug Type
Small molecular drug
Indication Chemotherapy-induced nausea [ICD9: 787, 787.0; ICD10:R11] Approved [536361], [539441]
Alcohol use disorders [ICD9: 303; ICD10:F10.2] Phase 2 [536361], [539441]
Therapeutic Class
Antiemetics
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C18H19N3O
InChI
InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
InChIKey
FELGMEQIXOGIFQ-UHFFFAOYSA-N
CAS Number
CAS 99614-02-5
PubChem Compound ID
4595
PubChem Substance ID
9533, 3206266, 3966923, 4696243, 7847522, 7980201, 8152820, 11137931, 11427135, 11467086, 11468206, 11486674, 11501532, 14873468, 29223684, 46504819, 47389509, 47686452, 47686453, 47909550, 47909551, 47984334, 48416352, 49698991, 49835876, 49901808, 50064204, 50949003, 53787007, 57322341, 58007430, 85174434, 85209216, 85787808, 85788905, 92309152, 93624973, 103166621, 103915041, 104170204, 104225172, 104306859, 105146690, 121362488, 124579243, 124893606, 125324981, 125360632, 125814185, 126525328
SuperDrug ATC ID
A04AA01
SuperDrug CAS ID
cas=099614025
Target and Pathway
Target(s) 5-Hydroxytryptamine 3 receptor Target Info Agonist [538141]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539441(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2290).
Ref 538141Treatment of pruritus in chronic liver disease with the 5-hydroxytryptamine receptor type 3 antagonist ondansetron: a randomized, placebo-controlled, double-blind cross-over trial. Eur J Gastroenterol Hepatol. 1998 Oct;10(10):865-70.

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