Drug General Information
Drug ID
D0K8LN
Former ID
DNC005486
Drug Name
1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527542]
Structure
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2D MOL

3D MOL

Formula
C18H19ClO2S
Canonical SMILES
C1CCC(CC1)(C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)Cl
InChI
1S/C18H19ClO2S/c19-16-9-11-17(12-10-16)22(20,21)18(13-5-2-6-14-18)15-7-3-1-4-8-15/h1,3-4,7-12H,2,5-6,13-14H2
InChIKey
XMYNJSLMUBGZIQ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Presenilin 1 Target Info Inhibitor [527542]
Presenilin 2 Target Info Inhibitor [527542]
KEGG Pathway Wnt signaling pathway
Notch signaling pathway
Neurotrophin signaling pathway
Alzheimer's diseasehsa04330:Notch signaling pathway
Alzheimer's disease
NetPath Pathway Notch Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Notch signaling pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
p75(NTR)-mediated signaling
Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling events
Reactome Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Notch Signaling Pathway
Alzheimers DiseaseWP61:Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Alzheimers Disease
Signalling by NGF
References
Ref 527542Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8.Aryl sulfones: a new class of gamma-secretase inhibitors.
Ref 527542Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8.Aryl sulfones: a new class of gamma-secretase inhibitors.

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