Drug General Information
Drug ID	D0K9UK
Former ID	DIB016607
Drug Name	E-6700
Indication	Asthma [ICD10:J45]		Phase 2	[534187]
Structure		Download 2D MOL 3D MOL
CAS Number	CAS 144562-61-8
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[534187]
	Thromboxane-A synthase	Target Info	Modulator	[534187]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosishsa00590:Arachidonic acid metabolism
	Platelet activation
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
	Phase 1 - Functionalization of compounds
References
Ref 534187	Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57.
Ref 534187	Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57.

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