Drug Information

Drug General Information
Drug ID
D0KD8D
Former ID
DNC005037
Drug Name
[2-(3-Benzyl-3H-indol-1-yl)-ethyl]-dimethyl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527212]
Structure
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2D MOL

3D MOL
Formula
C19H23N2+
Canonical SMILES
CN(C)CC[N+]1=CC(C2=CC=CC=C21)CC3=CC=CC=C3
InChI
1S/C19H23N2/c1-20(2)12-13-21-15-17(14-16-8-4-3-5-9-16)18-10-6-7-11-19(18)21/h3-11,15,17H,12-14H2,1-2H3/q+1
InChIKey
CEOWUNUFGJBATQ-UHFFFAOYSA-N
PubChem Compound ID
44393544
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527212]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527212Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73.Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.
Ref 527212Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73.Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.

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