Drug General Information
Drug ID	D0KV4Z
Former ID	DIB008978
Drug Name	CI-949
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[544546]
Company	Dura Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C26H34N10O5
Canonical SMILES	c1(n(c2c(c1OC(C)C)cc(cc2)OC)c1ccccc1)C(=O)Nc1nnn[nH]1.C<br />(=N)(NCCC[C@@H](C(=O)O)N)N
CAS Number	CAS 121530-58-3
PubChem Compound ID	159562
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Modulator	[528462]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544546	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000104)
Ref 528462	Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):902-8.

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