Drug General Information
Drug ID	D0L0AU
Former ID	DIB003395
Drug Name	DMPDDF
Synonyms	IDDB5773
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Terminated	[545832]
Company	Glaxo Wellcome plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c(=O)c2c([nH]c1N)ccc(c2)CN(c1ccc(C(=O)N[C@@H](C(=O)O)<br />CCC(=O)O)cc1)CC#C
Target and Pathway
Target(s)	Thymidylate synthase	Target Info	Inhibitor	[533040]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleoside salvage
	DTMP de novo biosynthesis (mitochondrial)
	Pyrimidine deoxyribonucleosides salvage
KEGG Pathway	Pyrimidine metabolism
	One carbon pool by folate
	Metabolic pathways
PANTHER Pathway	De novo pyrimidine deoxyribonucleotide biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	Pyrimidine biosynthesis
	G1/S-Specific Transcription
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Integrated Pancreatic Cancer Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 545832	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004963)
Ref 533040	Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. J Med Chem. 1989 Jun;32(6):1284-9.

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