Drug Information

Drug General Information
Drug ID
D0L0MB
Former ID
DAP000844
Drug Name
Acetophenazine
Synonyms
Acephenazinum; Acetophenazina; Acetophenazinum; Tindal; Acetophenazine [INN]; Acetophenazina [INN-Spanish]; Acetophenazinum [INN-Latin]; Ketone, 10-(3-(4-(2-hydroxyethyl-1-piperazinyl)propyl)phenothiazin-2-yl methyl; 1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanone; 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone; 10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone; 2-acetyl-10-[3-[4-(b-hydroxyethyl)piperazinyl]propyl]phenothiazine
Drug Type
Small molecular drug
Indication False perceptions; Bipolar disorder [ICD9: 297, 780.1, 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10:F22, R44, F31, F40-F42] Approved [538457], [551871]
Therapeutic Class
Antipsychotic Agents
Structure
Download
2D MOL

3D MOL
Formula
C23H29N3O2S
Canonical SMILES
CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)CCO
InChI
1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3
InChIKey
WNTYBHLDCKXEOT-UHFFFAOYSA-N
CAS Number
CAS 2751-68-0
PubChem Compound ID
17676
PubChem Substance ID
9026, 6906047, 7978635, 8145915, 8163237, 14981427, 29285397, 46507036, 48415507, 50064639, 50125831, 57329848, 79129243, 85209527, 103301246, 104343061, 108136254, 117565968, 126671572, 127339546, 127339547, 129608156, 134982102, 135653585, 136350446, 137102211, 142677075, 160964397, 179116543, 184546003, 198962966, 223666661, 226471888, 250102248
ChEBI ID
ChEBI:2401
SuperDrug ATC ID
N05AB07
SuperDrug CAS ID
cas=002751680
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [535384], [537772]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 538457FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012254.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535384Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.
Ref 537772Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients. Clin Pharmacol Ther. 1967 Mar-Apr;8(2):249-55.

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