Drug Information

Drug General Information
Drug ID
D0L1BS
Former ID
DIB007298
Drug Name
PF-454583
Synonyms
PF-454583; PF-4926965; Opioid receptor-like 1 (ORL1) antagonists (Alzheimer's disease), Pfizer
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Investigative [543766]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C21H26ClFN4O2
Canonical SMILES
CN(C)C(=O)C(CN1CCC2(CC1)C3=C(CO2)C=CC(=C3)F)CN4C=C(C=N4<br />)Cl
InChI
1S/C21H26ClFN4O2/c1-25(2)20(28)16(12-27-13-17(22)10-24-27)11-26-7-5-21(6-8-26)19-9-18(23)4-3-15(19)14-29-21/h3-4,9-10,13,16H,5-8,11-12,14H2,1-2H3
InChIKey
BVXVLXUGXQOMEP-UHFFFAOYSA-N
PubChem Compound ID
11690306
PubChem Substance ID
16794675, 23785024, 42857226, 77007051, 136350003, 139839375, 141520619, 230856120, 230856125, 244551406
Target and Pathway
Target(s) Nociceptin receptor Target Info Antagonist [543766]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).

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