TTD | Drug: D0L3EP

Drug General Information
Drug ID	D0L3EP
Former ID	DIB019945
Drug Name	GSK1614343
Synonyms	GSK-1614343; GSK 1614343
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541179]
Structure		Download 2D MOL
Formula	C22H23F6N5O
InChI	InChI=1S/C22H23F6N5O/c23-21(24,25)15-9-16(22(26,27)28)11-17(10-15)30-31-20(34)19(14-3-1-5-29-12-14)33-8-7-32-6-2-4-18(32)13-33/h1,3,5,9-12,18-19,30H,2,4,6-8,13H2,(H,31,34)/t18-,19-/m1/s1
InChIKey	QNOSCJDGJKVFJR-RTBURBONSA-N
PubChem Compound ID	25124566
PubChem Substance ID	56448801, 81009864, 141268416, 178102494, 224446736, 229635404, 243633898
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Antagonist	[531003]
KEGG Pathway	cAMP signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541179	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5870).
Ref 531003	Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists. ChemMedChem. 2010 Sep 3;5(9):1450-5.

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Drug Information