Drug Information

Drug General Information
Drug ID
D0L3MJ
Former ID
DIB020956
Drug Name
SKF-83959
Synonyms
SKF83959; SKF 83959
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533137]
Structure
Download
2D MOL
Formula
C18H20ClNO2
InChI
InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3
InChIKey
JXMYTVOBSFOHAF-UHFFFAOYSA-N
PubChem Compound ID
133538
PubChem Substance ID
10243394, 14752552, 29311436, 47425387, 50065236, 50104977, 50525629, 57344557, 85209559, 90340965, 103695208, 103805509, 104118280, 104140316, 104380016, 117460295, 124750212, 124881424, 126437683, 128341787, 134223246, 135087983, 135610667, 137010205, 139740362, 179294253, 229030508, 246793511, 252166653
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Agonist [533137]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 533137Identification of G protein-biased agonists that fail to recruit beta-arrestin or promote internalization of the D1 dopamine receptor. ACS Chem Neurosci. 2015 Apr 15;6(4):681-92.
Ref 533137Identification of G protein-biased agonists that fail to recruit beta-arrestin or promote internalization of the D1 dopamine receptor. ACS Chem Neurosci. 2015 Apr 15;6(4):681-92.

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